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New experimental models for aromatase inhibitor resistance

✍ Scribed by Shiuan Chen; Selma Masri; Yanyan Hong; Xin Wang; Sheryl Phung; Yate-Ching Yuan; Xiwei Wu

Book ID
116698081
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
504 KB
Volume
106
Category
Article
ISSN
0960-0760

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The authors developed a breast cancer intratumoral aromatase model system to compare the antitumor efficacy of several aromatase inhibitors (AIs) and antiestrogens (AEs). Although the AI letrozole caused sustained growth inhibition, tumors eventually began to grow, even when treatment was maintained