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Pharmacophore Modeling and in Silico Screening for New P450 19 (Aromatase) Inhibitors †

✍ Scribed by Schuster, Daniela; Laggner, Christian; Steindl, Theodora M.; Palusczak, Anja; Hartmann, Rolf W.; Langer, Thierry

Book ID
118243884
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
373 KB
Volume
46
Category
Article
ISSN
0095-2338

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## Abstract Dipeptidyl peptidase IV (DPP IV) deactivates the natural hypoglycemic incretin hormones. Inhibition of this enzyme should restore glucose homeostasis in diabetic patients making it an attractive target for the development of new antidiabetic drugs. With this in mind, the pharmacophoric