New Eremophilanolides from Ligularia hodgsonii

✍ Scribed by Yang-Jun Xu; Ze-Dong Nan; Wen-Hai Li; Hong-Li Huang; Cheng-Shan Yuan

• Book ID: 102256836
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: German
• Weight: 180 KB
• Volume: 92
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200800250

✦ Synopsis

A phytochemical study on the roots and rhizomes of Ligularia hodgsonii led to the isolation of seven new eremophilanolides (1 -7), their structures were established as (1R,4S,5S,6R,8S,10R)-1-acetoxyeremophil-7(11)-en-6,15;8,12-diolide (1), (1R,4S,5S,6R,8S,10R)-1-acetoxy-8b-hydroxyeremophil-7( 11)-en-6,15;8,12-diolide (2), (4S,5S,6R,8R,9S,10S)-8-hydroxy-9-(angeloyloxy)eremophil-7( 11)-en-6,15;8,12-diolide (3), (4S,5S,6R,10R)-10-hydroxyeremophil-7(11),8( 9)-diene-6,15;8,12-diolide (4), (4S,5S,6R,8R, 10R)-6-(angeloyloxy)-8-hydroxyeremophil-7(11)-en-8,12-olide-15-carboxylic acid methyl ester ( 5), (4S,5S,6R,8R,10R)-6-(angeloyloxy)-8-ethoxyeremophil-7(11)-en-8,12-olid-15-oic acid ( 6), (4S,5S,6S, 8R,10R)-6-(angeloyloxy)-8-ethoxyeremophil-7(11)-en-8,12-olid-15-oic acid ( 7) by means of spectroscopic analyses. The compounds were also evaluated for antibacterial activity, only compound 6 exhibited antibacterial activity against Bacillus subtilis.