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New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury

✍ Scribed by Santiago, Fernando S.; Lowe, Harry C.; Kavurma, Mary M.; Chesterman, Colin N.; Baker, Andrew; Atkins, David G.; Khachigian, Levon M.


Book ID
109542002
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
731 KB
Volume
5
Category
Article
ISSN
1078-8956

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## Abstract Smooth muscle cell (SMC) migration and proliferation are key events in the pathogenesis of atherosclerotic and post‐angioplasty restenotic lesions. Mechanical injury to the artery wall induces the SMC expression of the zinc finger transcription factor, early growth response factor‐1 (Eg