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New developments in palladium catalysed cross coupling: The coupling of alkyl iodides with alkyl Grignard reagents

✍ Scribed by Paul L Castle; David A Widdowson

Book ID
104219464
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
189 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Sumnary -The species generated by the in situ reduction of l,l'-bis(di--phenylphosphino)ferrocenepalladium dichl3&?s an effective catalyst for the cross coupling of alkyl iodides with alkyl Grignard reagents. 4 9 Isolated yields of major products, relative yields determined by g.1.c. analysis, no olefins from B-elimination reactions were detectable. This arises by homo-coupling when Grignard reagent formation is incomplete. No detectable yield. Ambient temperature. Also detected: 4-bromoanisole (37%).

Refluxing THF solution.

Also detected: anisole (83x1, the product of proton quenching of unreacted Grignard reagent.

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