New developments in natural products-based anti-AIDS research

✍ Scribed by Donglei Yu; Susan L. Morris-Natschke; Kuo-Hsiung Lee

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 345 KB
• Volume: 27
• Category: Article
• ISSN: 0198-6325
• DOI: 10.1002/med.20075

✦ Synopsis

Abstract

This review discusses anti‐HIV natural products from several compound classes, including terpenoids, coumarins, alkaloids, polyphenols, tannins, and flavonoids. Natural products can provide novel anti‐AIDS chemotherapeutic leads that are structurally unique or have new mechanisms of action. The drug discovery and development process proceeds from bioactivity‐directed isolation and identification of a promising lead natural product, followed by rational design‐based structural modification and structure–activity relationship analyses to optimize the lead compound as a drug candidate. This process is notably exemplified by the discovery of the modified betulinic acid derivative, DSB [PA‐457], which is currently in Phase II clinical trial and is the first‐in‐class HIV maturation inhibitor (MI). © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 1, 108–132, 2007