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New derivatives of dibenzo[b,e][1,4]diazepin-1-ones by an efficient synthesis and spectroscopy

✍ Scribed by Eduardo Cortés Cortés; Ana L. Valencia Cornejo; Olivia García-Mellado de Cortés

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
290 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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An efficient synthesis of four steps to obtain twelve new derivatives of 3,3‐dimethyl‐2,3,4,5,10,11‐hexahydro‐8‐[(o‐; and p‐methoxy)phenoxy]‐11‐[(o‐; and p‐R)phenyl]‐1__H__‐dibenzo[b,e][1,4]diazepin‐1‐ones IV, 1‐12 with possible biological and pharmacological activity as anticonvulsant and schizophrenia treatment in the central nervous system (CNS). The final products were obtained by condensation and cyclization between 3‐{4‐[(o‐; and p‐methoxy)phenoxy]‐1,2‐phenylenediamine}‐5,5‐dimethyl‐2‐cyclohexenone with (o‐; and p‐R)benzaldehyde. The structure of all products was corroborated by spectroscopy of ir, ^1^H‐nmr, ^13^C‐nmr, with bidimensional experiments and MS in Low and high resolution with Collision‐Induced Dissociation experiments (CID).

📜 SIMILAR VOLUMES

New Derivatives of Dibenzo[b,e][1,4]diaz
New Derivatives of Dibenzo[b,e][1,4]diazepin-1-ones by an Efficient Synthesis and Spectroscopy.
✍ Eduardo Cortes Cortes; Ana L. Valencia Cornejo; Olivia Garcia-Mellado de Cortes 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 22 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform Abstract: Efficient Synthesis
ChemInform Abstract: Efficient Synthesis and Spectroscopy of 3,3-Dimethyl-2,3,4,5,10,11-hexahydro-8-[(o-; and p-methyl)phenoxy]-11-[(o; and p-substituted)phenyl]-1H-dibenzo-[b,e][1,4]diazepin-1-ones.
✍ Eduardo Cortes Cortes; Ociel E. Andrade Meneses; Olivia Garcia-Mellado; Olefia C 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v