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New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome

✍ Scribed by Shakunthala, Narasimhulu


Book ID
111656625
Publisher
Informa plc
Year
2009
Tongue
English
Weight
997 KB
Volume
6
Category
Article
ISSN
1742-5255

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## Abstract We describe a system setup that is applicable to all species in the catalytic cycle of cytochrome P450~cam~. The chosen procedure starts from the X‐ray coordinates of the ferrous dioxygen complex and follows a protocol that includes the careful assignment of protonation states, comparis