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A Mechanism-Based Pharmacokinetic Model for the Cytochrome P450 Drug–Drug Interaction between Cyclophosphamide and ThioTEPA and the Autoinduction of Cyclophosphamide

✍ Scribed by Alwin D. R. Huitema; Ron A. A. Mathôt; Matthijs M. Tibben; Sjoerd Rodenhuis; Jos H. Beijnen


Book ID
110303375
Publisher
Springer
Year
2001
Tongue
English
Weight
159 KB
Volume
28
Category
Article
ISSN
1573-8744

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## Abstract ## Background AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4. Most solid tumours are known to contain regions of hypoxia whereas levels of CYPs have been found to vary considerably. Enhancement of CYP levels may be obtained using gene‐directed enzy