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New compounds: Derivatives of fluorene XXXVII: 9-substituted 3-nitrofluorenes

✍ Scribed by Hsi-Lung Pan; Carol-Ann Cole; T. Lloyd Fletcher

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
252 KB
Volume
69
Category
Article
ISSN
0022-3549

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✦ Synopsis

New 9-substituted 3-nitrofluorenes were prepared as potential intermediates in a study of modified electrophilicity and mutagenicity of the carcinogen 3-N,Odiacetylhydroxylaminofluorene. The reported derivatives, together with some already known 9-substituted 3-nitrofluorenes, were too unstable to survive the reducing conditions required to transform the nitro group to the corresponding hydroxylamine.

Keyphrases 0 Fluorenes-synthesis of 3-nitro-9-substituted derivatives, potential enhancement of 3-N,Odiacetylhydroxylaminofluorene carcinogenicity 0 3-N,O-Diacetylhydroxylaminofluorene-synthesis of 9-substituted 3-nitrofluorene intermediates, effect on carcinogenicity Carcinogens-synthesis of 9-substituted 3-nitrofluorene intermediates for study of 3-N,O-diacetylhydroxylaminofluorene mutagenicity Model M-911, Gaertner Scientific Corp., Chicago, IL 60614.

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