New Chiral Phosphine−Phosphite Ligands in the Enantioselective Palladium-Catalyzed Allylic Alkylation
✍ Scribed by Deerenberg, Sirik; Schrekker, Henri S.; van Strijdonck, Gino P. F.; Kamer, Paul C. J.; van Leeuwen, Piet W. N. M.; Fraanje, Jan; Goubitz, Kees
- Book ID
- 125516953
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 181 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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## Abstract magnified image Chiral ferrocene‐derived phosphine‐thioether mixed donor ligands supported by heterocycles effected the palladium‐catalyzed enantioselective allylic alkylations with excellent yields and enantioselectivities (up to 96% __ee__). With cyclic and unsymmetrical allylic acet
Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (8a) with a dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of novel chiral phosphine-oxazinane ligands such as 5b in good yields with good enantioselectivities (up to 95% ee).