New Chiral N, 5-Ligands with Thiophenyl at Benzylic Position. Palladium (II)-catalyzed Enantioselective Allylic Alkylation

✍ Scribed by Hao Wu; Xun-Wei Wu; Xue-Long Hou; Li-Xin Dai; Quan-Rui Wang

• Book ID: 102096444
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 213 KB
• Volume: 20
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.20020200903

✦ Synopsis

Abstract

New chiral N, S‐ligands with oxazoline and thiophenyl substituents at benzene ring and benzylic position have been prepared and applied in palladium‐catalyzed asymmetric allylic alkylation reaction to provide the product with high yield and entantioselectivity (82%–93% ee).