New Chiral Auxiliaries for Highly Stereoselective Asymmetric Methoxyselenenylations
โ Scribed by Back, Thomas G.; Moussa, Ziad
- Book ID
- 127143278
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 51 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
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๐ SIMILAR VOLUMES
New chiral auxiliaries based on the bicyclic-isoxazolidine skeleton, 3-oxa-2,7diazabicylo[3,3,0]octane derivatives, were synthesized in 60-80% overall yields from amino acids. Asymmetric alkylation and boron aldol reaction using the auxiliaries proceeded with high selectivities. "Carboxylic amide" h
New Isoxazolidine-Based Chiral Auxiliaries for Asymmetric Syntheses. -A series of title compounds such as (I) is prepared and tested as auxiliaries. Asymmetric alkylation and boron aldol reactions proceed with excellent selectivity with the derivatives (III) and (VI), respectively. -
Diketopiperazines have been utilized as chiral auxiliaries for asymetric Diels-Alder reactions. Cyclo-Sphenylalanyl-R-proline (2) was found to be the most promising of these auxiliaries and afforded Diels-Alder adducts in high chemical yield (78 -95%), with endo selectivities generally greater than