๐”– Bobbio Scriptorium
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New chemistry of mitomycin C

โœ Scribed by T. Kaneko; H. Wong; T.W. Doyle

Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
202 KB
Volume
26
Category
Article
ISSN
0040-4039

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In 10 human cancer cell lines, the activity of mitomycin C (MMC) was found to be determined by an interplay between activation by DT-diaphorase (DTD) and inactivation by glutathione S-transferase (GST). NADPH/cytochrome P-450 reductase was not responsible for MMC activation and expression of MDR1 (M