Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver
โ Scribed by Kimihiko Sato; Kazue Itakura; Koyo Nishida; Yoshinobu Takakura; Mitsuru Hashida; Hitoshi Sezaki
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 576 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Using the in situ perfused rat liver model, the effect of erythromycin (Ery) on the disposition of cyclosporin A (CyA) and the major human metabolite, AMl, was investigated. Prior to perfusion experiments, oral dosing was carried out for three days on three groups of male Sprague-Dawley rats (300-35
The relation between the rate of glutathione (GSH) conjugation and hepatic GSH content was studied in the rat in uiuo and the in situ single-pass-perfused rat liver preparation with bromosulfophthalein (BSP) as the model substrate. The biliary excretion of the BSP-GSH conjugate and the hepatic GSH c