✦ LIBER ✦

The effect of three H2 receptor antagonists on the disposition of cyclosporin a in the in situ perfused rat liver model

✍ Scribed by C. M. Hughes; J. G. Swanton; P. S. Collier

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 839 KB
Volume: 16
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510160903

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Cyclosporin A and erythromycin: A study

Cyclosporin A and erythromycin: A study of a drug interaction in the in situ perfused rat liver model

✍ C. M. Hughes; J. G. Swanton; P. S. Collier 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

Using the in situ perfused rat liver model, the effect of erythromycin (Ery) on the disposition of cyclosporin A (CyA) and the major human metabolite, AMl, was investigated. Prior to perfusion experiments, oral dosing was carried out for three days on three groups of male Sprague-Dawley rats (300-35

Effect of H2-receptor antagonists on the

Effect of H2-receptor antagonists on the pharmacokinetics of 5-fluorouracil in the rat and monkey

✍ Mark R. Dilloway; F. Lant 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 530 KB

The effect of short term (7 days) and long term (28 days) pretreatment with the imidazole H,-receptor antagonist, cimetidine (CMT), on the pharmacokinetics of 5-fluorouracil (5-FUra) has been studied in the rat and cynomolgus monkey. Short-term pretreatment of rats with CMT significantly increased b

Primaquine disposition in the isolated p

Primaquine disposition in the isolated perfused rat liver: Effect of mefloquine induced bile flow reduction

✍ Michael D. Coleman; Lawrence Fleckenstein; Melvin H. Heiffer 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 524 KB

The disposition of primaquine (0.75 mg, 5 pC1) has been investigated in the isolated perfused rat liver (IPRL) preparation alone and concurrently with mefloquine. In both groups, primaquine concentrations declined exponentially. There were no significant differences between the respective groups in

Effect of verapamil on glycogenolysis an

Effect of verapamil on glycogenolysis and gluconeogenesis in the perfused rat liver

✍ Badr, Mostafa 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 303 KB 👁 1 views

In perfused livers from fed rats, rates of glucose production (glycogenolysis) were 133 f 12 pmollglhr. Infusion of 2 pM verapamil into these livers decreased the rates of glucose production significantly to 97 \* 15 pmollglhr within 10 min. Conversely, rates of production of lactate plus pyruvate (

The effect of domperidone on theophyllin

The effect of domperidone on theophylline disposition in the rat

✍ S. A. Bawazir; M. I. Al-Hassan; K. M. Matar; A. Tekle 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB 👁 2 views

The effect of domperidone (2 mg kg-') on the pharmacokinetics of a single oral dose of theophylline (25 mg kg-') was studied in the rat. Theophylline concentrations were measured serially for 12 h using an HPLC technique. Domperidone did not have any significant effect on any of the four parameters

Effect of vasodilators on hepatic microc

Effect of vasodilators on hepatic microcirculation in cirrhosis: A study in the isolated perfused rat liver

✍ Philippe Marteau; François Ballet; Olivier Chazouillères; Yves Chrétien; Colette 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 489 KB 👁 1 views

We studied the effects of a series of vasodilators on intrahepatic vascular resistance of isolated perfused cirrhotic rat livers in basal conditions and during norepinephrine-induced vasoconstriction. Cirrhosis was induced by repeated intraperitoneal injections of carbon tetrachloride. The vasodilat