New Bis-thiazolium Analogues as Potential Antimalarial Agents: Design, Synthesis, and Biological Evaluation
✍ Scribed by Caldarelli, Sergio A.; El Fangour, Siham; Wein, Sharon; Tran van Ba, Christophe; Périgaud, Christian; Pellet, Alain; Vial, Henri J.; Peyrottes, Suzanne
- Book ID
- 118213551
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 911 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-2623
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies.