New Aspects of the Koch Carboxylic Acid Synthesis

✍ Scribed by K. E. Möller

• Publisher: John Wiley and Sons
• Year: 1965
• Tongue: English
• Weight: 242 KB
• Volume: 4
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.196505353

✦ Synopsis

Metabolic products of cancer cells have an inhibiting action on catalase. That healthy cells also contain catalase inhibitors was shown by inhibition experiments, chiefly with cell extracts from chicken embryos, which are characterized by accelerated cell growth similar to cancer tissue. Thermostable, dialysable catalase-inhibitors were found in decreasing concentrations in liver, heart, and brain. I n the cells of these organs, the inhibitors are distributed in decreasing amounts in mitochondria, cell nuclei, and cell membranes. Nothing is known about the chemical character of these inhibitors. Catalase-inhibitors of known constitution fall into three groups: diphenols, metabolic products of tryptophane or 5-hydroxytryptophane, and quaternary ammonium compounds. Tryptamine and serotonin, which are substrates of amine oxidase, belong to the second group. Besides the hydrazides, iodine derivatives of noradrenaline and tyramine are inhibitors for amine oxidase. It must be assumed that amine oxidase-inhibiting substances also occur in cell extracts.

[GDCh-Ortsverband Mainz (Germany),