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New approaches to the pyrrolizidine ring system: total synthesis of (.+-.)-isoretronecanol and (.+-.)-trachelanthamidine

✍ Scribed by Pinnick, Harold W.; Chang, Yeong-Ho


Book ID
125861657
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
315 KB
Volume
43
Category
Article
ISSN
0022-3263

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## Abstract magnified image Canthin‐4‐one, as well as 5‐ and 6‐alkylcanthin‐4‐ones are readily available through reaction of 1‐acyl‐β‐carbolines with Bredereck's reagent or dimethylacetamide acetals in anhydrous DMF. The intermediate enaminoketones readily undergo cyclization to the canthin‐4‐ones