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New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes

✍ Scribed by Iman Saramipoor Behbahan; Yuyou Duan; Alexander Lam; Shiva Khoobyari; Xiaocui Ma; Tijess P. Ahuja; Mark A. Zern

Publisher
Humana Press Inc
Year
2011
Tongue
English
Weight
370 KB
Volume
7
Category
Article
ISSN
1550-8943

No coin nor oath required. For personal study only.

✦ Synopsis

Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field.

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