New Approach to the Synthesis of (2RS,4"R,8"R)-α-Tocopherol (Vitamin E)
✍ Scribed by Odinokov, V. N.; Mallyabaeva, M. I.; Spivak, A. Yu.; Emel'yanova, G. A.; Dzhemilev, U. M.
- Book ID
- 110308539
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 37 KB
- Volume
- 380
- Category
- Article
- ISSN
- 0012-5008
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Compound \_7 (l',l'-D2-a-T) (see Scheme 3) was synthesized ( 9 ) via a sodium methoxide/CH,OD ring-opening of the methyl ester, 1'7, to give the 4 5.
## Abstract As an extension of previous studies on the total synthesis of (2R,4′R,8′R)‐α‐tocopherol (**1**) [1] [2], (S)‐(−)‐2‐(6‐benzyloxy‐2,5,7,8‐tetramethylchroman)acetic acid (**6**), a pivotal intermediate, possessing the absolute configuration required for construction of **1** was prepared b
## Abstract (2 __S__, 4′__R__, 8′__R__)‐α‐Tocopherol with unnatural configuration at C‐2 is prepared by oxidation of natural, so called __d__‐α‐tocopherol (I), which has the (2__R__, 4′__R__, 8′__R__)‐configuration, to α‐tocopherylquinone (II), followed by recyclization of the corresponding α‐tocop
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