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New and Highly Efficient Immonium Type Peptide Coupling Reagents: Synthesis, Mechanism and Application

โœ Scribed by Peng Li; Jie-Cheng Xu

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
176 KB
Volume
56
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

AbstractรA series of novel immonium type coupling reagents BOMI, BDMP, BPMP, DOMP, SOMP, FOMP and AOMP were designed and synthesized. It was shown that most of these reagents were more efยฎcient in peptide synthesis than conventional methods due to the advantages of high reactivity, low racemization and good yields. The reaction mechanism was proposed and studied by 1 H NMR, IR, UV and HPLC.

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