AbstractรA series of novel immonium type coupling reagents BOMI, BDMP, BPMP, DOMP, SOMP, FOMP and AOMP were designed and synthesized. It was shown that most of these reagents were more efยฎcient in peptide synthesis than conventional methods due to the advantages of high reactivity, low racemization
Design and Synthesis of New Immonium-Type Coupling Reagents
โ Scribed by Ayman El-Faham; Sherine N. Khattab; Mohamed Abdul-Ghani; Fernando Albericio
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 171 KB
- Volume
- 2006
- Category
- Article
- ISSN
- 1434-193X
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An efficient scalable synthesis of 2-halothiazolium-type peptide coupling reagents has been developed. The key step is the formation of the 2-bromothiazole scaffold through cyclization of a-thiocyanato ketones with hydrogen bromide. Using this method, the new coupling reagent 2-bromo-N-methylthiazol