New and direct route to 5-trifluoromethyl-5,6-dihydrouracils by means of palladium complex catalyzed “ureidocarbonylation” of 2-bromo-3,3,3-trifluoropropene

Palladium-Catalyzed Amination and Sulfon

Palladium-Catalyzed Amination and Sulfonylation of 5-Bromo-3-[2-(diethylamino)ethoxy]indoles to Potential 5-HT6 Receptor Ligands

✍ Nicolle Schwarz; Anahit Pews-Davtyan; Dirk Michalik; Annegret Tillack; Karolin K 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB 👁 1 views

## Abstract A general and efficient palladium‐catalyzed amination of 5‐bromo‐3‐[2‐(diethylamino)ethoxy]indoles has been developed. Best results are obtained in the presence of Pd(OAc)~2~ and 2‐[di(1‐adamantyl)phosphanyl]‐1‐phenylpyrrole as ligand. Subsequent sulfonylation gave novel indole derivati