Palladium-Catalyzed Amination and Sulfonylation of 5-Bromo-3-[2-(diethylamino)ethoxy]indoles to Potential 5-HT6 Receptor Ligands

✍ Scribed by Nicolle Schwarz; Anahit Pews-Davtyan; Dirk Michalik; Annegret Tillack; Karolin Krüger; Antoni Torrens; José Luis Diaz; Matthias Beller

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 301 KB
• Volume: 2008
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200800638

✦ Synopsis

Abstract

A general and efficient palladium‐catalyzed amination of 5‐bromo‐3‐[2‐(diethylamino)ethoxy]indoles has been developed. Best results are obtained in the presence of Pd(OAc)~2~ and 2‐[di(1‐adamantyl)phosphanyl]‐1‐phenylpyrrole as ligand. Subsequent sulfonylation gave novel indole derivatives, which are of interest as potentially biological active 5‐HT~6~ receptor ligands.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)