New Alicyclic Musks: The Fourth Generation of Musk Odorants

✍ Scribed by Marcus Eh

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 182 KB
• Volume: 1
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200490151

✦ Synopsis

Abstract

Musk odorants are one of the most important classes of fragrances in perfumery because they impart sensuality to perfume‐oil compositions. Among the three well‐known classes of musks, a new and very exciting generation of musk odorants, the so‐called alicyclic musks, was discovered recently, of which Helvetolide^®^ (2) and Romandolide^®^ (3) are the most popular representatives so far. To find new, structurally related alicyclic musks, we have synthesized a library of 114 unique alicyclic molecules with modified cyclohexyl moieties. The olfactory properties of all compounds were evaluated to identify the structural requirements to be met for a musk odorant.