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New access to thiazolo[4,5-d]pyrimidine derivativess

✍ Scribed by M. Bakavoli; M. Nikpour; M. Rahimizadeh

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
181 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Cl

1 -R 2 NH, EtOH, heat 2 -NaNH 2 , DMF, R'NCS R'

4-Amino-5-bromo-2-substituted-aminopyrimidines are readily obtained from the newly prepared 5bromo-2,4-dichloro-6-methylpyrimidine by sequential treatment with ethanolic ammonia and secondary amines. These compounds were successfully reacted with various isothiocyanates in the presence of sodamide in DMF to form the new thiazolo [4,5-d] pyrimidine derivatives .

📜 SIMILAR VOLUMES

Über einige Thiazolo [5,4-d] pyrimidine
Über einige Thiazolo [5,4-d] pyrimidine II
✍ H. v. Hahn; H. Erlenmeyer 📂 Article 📅 1956 🏛 John Wiley and Sons 🌐 German ⚖ 226 KB

## Abstract Several 2‐substituted 7‐mercapto‐thiazolo[5,4‐d]pyrimidines were synthesized from 4,6‐dimercapto‐5‐amino‐pyrimidines by reaction with acid anhydrides or mid chlorides.