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New [11C]Phosgene Based Synthesis of [11C]Pyrimidines for Positron Emission Tomography

✍ Scribed by Seki, Koh-ichi; Ohkura, Kazue; Sanoki, Kimihito; Nishijima, Ken-ichi; Tamaki, Nagara; Kuge, Yuji; I. Wiebe, Leonard; Takahashi, Masayuki; Akizawa, Hiromichi


Book ID
120067084
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
328 KB
Volume
77
Category
Article
ISSN
0385-5414

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The present study describes a rapid synthesis method for labeled [ 11 C]FK506 for positron emission tomography (PET). A one-pot reaction from [ 11 C]CH 3 I, involving a Wittig reaction as the key carbon carbon bond formation was developed. The chemical process was accomplished using a designed, full