Neutrophilic fixed drug eruption
β Scribed by Karen L Agnew; G Fergus Oliver
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 145 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-8380
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β¦ Synopsis
SUMMARY
A 49βyearβold man presented with a reproducible, localized amoxycillinβclavulanic acidβinduced eruption. The histopathology from lesional skin revealed a neutrophilic dermatosis. These histological findings have not been reported in previous fixed drug eruptions. A brief review is undertaken comparing fixed drug eruption and the group of neutrophilic dermatoses with our case presentation. We propose a new entity of neutrophilic fixed drug eruption.
π SIMILAR VOLUMES
Eighty years have elapsed since fixed drug eruption was described (Brocq, 1894) but the mechanism of production is still unknown. Both immunological and toxic mechanisms have been implicated to explain the abnormal response of the skin to the administered drug, but there is no supporting evidence in
A case of a previously unrecognized form of hypersensitivity to procarbazine characterized by a nonpigmented fixed drug eruption is reported. Despite skin testing, association of the skin lesion to procarbazine could be determined only by drug rechallenge. Various aspects of procarbazine hypersensit