Neutrophil aggregating properties of PAF-acether and leukotriene B4
✍ Scribed by A.W. Ford-Hutchinson
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 339 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0192-0561
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## Abstract Leukotrene (LT) B~4~ activates human polymorphonuclear neutrophils. (PMN) by binding to plasmalemmal receptors. It stimulates PMN to raise cytosolic calcium and degranulate. Both responses end within 15–30 sec. However, in < 15 sec, LTB~4~‐treated PMN lose the ability to respond further
Human neutrophils biosynthesize the chemoattractant leukotriene B4 (LTB4) and metabolize LTB4 to omega oxidative products 20-hydroxy-LTB4 (20-OH-LTB4) and 20-carboxy-LTB4 (20-COOH-LTB4). In this study, we prepared the C-1 methyl ester and N-methyl amide of LTB4 and then examined neutrophil chemotaxi