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Neutral ceramidase gene: role in regulating ceramide-induced apoptosis

✍ Scribed by Moonsuk S. Choi; Mary A. Anderson; Zhongjian Zhang; Drazen B. Zimonjic; Nicolae Popescu; Anil B. Mukherjee


Book ID
117521417
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
542 KB
Volume
315
Category
Article
ISSN
0378-1119

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## Abstract Melanoma differentiation associated gene‐7/interleukin‐24 (__mda__‐7/IL‐24) uniquely displays broad cancer‐specific apoptosis‐inducing activity through induction of endoplasmic reticulum (ER) stress. We hypothesize that ceramide, a promoter of apoptosis, might contribute to __mda__‐7/IL