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Neurotropism of a high-passage XJ strain of junín virus

✍ Scribed by José R. Oubiña; Dr. Guadalupe Carballal

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
360 KB
Volume
15
Category
Article
ISSN
0146-6615

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✦ Synopsis

Guinea pig infection with a highly passaged XJ prototype strain of Junin virus by the intramuscular route (IM) was carried out in order to study viral tropism modification in this host. The neurotropism of this strain was demonstrated by viral isolation, meningitis, and by the presence of Junin antigens as shown by immunofluorescence. These events, not previously observed with the same lowerpassaged strain, revealed the appearance of neurotropism after multiple passages in guinea pigs.

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Intracerebral infection of cebus apella
Intracerebral infection of cebus apella with the XJ-clone 3 strain of Junín virus
✍ Dr. Guadalupe Carballal; José R. Oubiña; Cristina Videla; Felisa C. Molinas; Car 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 760 KB

To assess the usefulness of the South American primate Cebus apella as a model for neurovirulence of Junín virus, eight monkeys were inoculated with 10(5) LD50 of the attenuated XJ-Clone 3 Junín virus strain by the intrathalamic route. After the second week, weight loss and polyadenopathies were obs