Genomic Features of Attenuated Junín Virus Vaccine Strain Candidate
✍ Scribed by Sandra Elizabeth Goñi; Javier Alonso Iserte; Ana Maria Ambrosio; Victor Romanowski; Pablo Daniel Ghiringhelli; Mario Enrique Lozano
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 162 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0920-8569
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Guinea pig infection with a highly passaged XJ prototype strain of Junin virus by the intramuscular route (IM) was carried out in order to study viral tropism modification in this host. The neurotropism of this strain was demonstrated by viral isolation, meningitis, and by the presence of Junin anti
To assess the usefulness of the South American primate Cebus apella as a model for neurovirulence of Junín virus, eight monkeys were inoculated with 10(5) LD50 of the attenuated XJ-Clone 3 Junín virus strain by the intrathalamic route. After the second week, weight loss and polyadenopathies were obs