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Neurotropic and antitumor activities of silyl- and germyl-isoxazolin-2-yl derivatives

✍ Scribed by E. Lukevics; P. Arsenyan; S. Germane; I. Shestakova

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 37 KB
Volume: 13
Category: Article
ISSN: 0268-2605
DOI: 10.1002/(sici)1099-0739(199910)13:10<795::aid-aoc909>3.0.co;2-v

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✦ Synopsis

Neurotropic and antitumor activities of the pyridyl-substituted 5-Si(Ge)-isoxazolines and (3alkyl-4-triphenylgermylisoxazolin-2-yl)-5-carboxylic acid ethyl esters have been investigated. It has been shown that silylisoxazolin-2-yl derivatives are more potent in protection against hypoxia and Corazole convulsions than their analogues. Germylisoxazolin-2-yl compounds are stronger tumor growth inhibitors and NOinducers than their silyl analogues.

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