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Neurotrophic effect of nerve extract on development of tetrodotoxin-sensitive spike potential in skeletal muscle cells in culture

✍ Scribed by Masaakira Kano; Nobuyuki Suzuki; Hisayuki Ojima

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
432 KB
Volume
99
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The effect of the presence of nerve extracts on the development of tetrodotoxin (TTX)‐sensitive sodium channels in cultures of dissociated embryonic chick skeletal muscle cells was examined by measuring the maximum rate of rise of TTX‐sensitive spike potential. The addition of the nerve extract prepared from brain or spinal cord of chick embryos to the culture medium caused an increase in the channel density. Extracts of non‐neural tissues, i.e., lung, kidney, and muscle, were ineffective Liver extract, however, produced an effect similar to the nerve extracts. These resutls suggest that the TTX‐sensitive sodium channels in the muscle cell membrane are regulated by a diffusible chemical substance independently of innervation, and that this substance resides in neural tissues, and perhaps also in liver.

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