Neurotransmitter Transporters

✍ Scribed by K. Nørgaard-Nielsen, U. Gether (auth.), Prof. Dr. Harald H. Sitte, Prof. Dr. Michael Freissmuth (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2006
• Tongue: English
• Leaves: 548
• Series: Handbook of Experimental Pharmacology 175
• Edition: 1
• Category: Library

✦ Synopsis

The present volume of the Handbook of Experimental Pharmacology gives a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It aims to provide an overview of insights that were generated in the past five years. The volume serves as both a useful compendium of current concepts and an inspiring starting point, and will be a source for students interested in this emerging field as well as for experienced scientists looking for an update.

This volume is the brainchild of the editor-in-chief of the HEP series, Klaus Starke, awe-inspiring to all pharmacologists of younger generations

✦ Table of Contents

Zn 2+ Modulation of Neurotransmitter Transporters....Pages 1-22
Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concentrations to Study Binding Kinetics and Stoichiometry in Transporters....Pages 23-57
Structure/Function Relationships in Serotonin Transporter: New Insights from the Structure of a Bacterial Transporter....Pages 59-73
The Importance of Company: Na + and Cl − Influence Substrate Interaction with SLC6 Transporters and Other Proteins....Pages 75-93
Currents in Neurotransmitter Transporters....Pages 95-111
Mutational Analysis of Glutamate Transporters....Pages 113-135
The Diverse Roles of Vesicular Glutamate Transporter 3....Pages 137-150
Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency....Pages 151-180
The Role of SNARE Proteins in Trafficking and Function of Neurotransmitter Transporters....Pages 181-196
Regulation of the Dopamine Transporter by Phosphorylation....Pages 197-214
The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action....Pages 215-232
Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Plasma Membrane....Pages 233-249
Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutive and Regulated Trafficking....Pages 251-275
Regulation and Dysregulation of Glutamate Transporters....Pages 277-303
Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle-Associated Trimeric G Proteins: New Jobs for Long-Known Signal Transduction Molecules....Pages 305-325
Human Genetics and Pharmacology of Neurotransmitter Transporters....Pages 327-371
ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?....Pages 373-415
Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dysfunction, Affective Disorders, and Somatic Syndromes....Pages 417-456
Lessons from the Knocked-Out Glycine Transporters....Pages 457-483
The Norepinephrine Transporter in Physiology and Disease....Pages 485-524
The High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice....Pages 525-544

✦ Subjects

Pharmacology/Toxicology; Pharmacy; Neurosciences; Cell Biology