Neurotransmitter Interaction and Compartmentation

✍ Scribed by E. George Gray, Phillip R. Gordon-Weeks, Robert D. Burgoyne (auth.), H. F. Bradford (eds.)

• Publisher: Springer US
• Year: 1982
• Tongue: English
• Leaves: 824
• Series: NATO Advanced Study Institutes Series 48
• Edition: 1
• Category: Library

✦ Synopsis

The NATO Advanced Study Institute held in the Hotel Metropole Llandrindod Wells, Powys, Wales from July 26th to August 4th 1981 provided an excellent platform for presentation and appraisal of our current knowledge of neurotransmitter systems. The proceed­ ings comprise the present volume and these were arranged to allow study of the pathways and the interactions of specific transmitter systems, one with another, in the various sub-regions of the central nervous system. In addition several of the key factors involved in neurotransmitter release were highlighted. These include the structural and molecular organisation of the nerve terminal, its organelles (such as vesicles, neurotubules and synaptic densities) and the mechanisms involved in neurotransmitter release including the participation of calcium. The organisation of transmitter synthesis, storage and transport were discussed together with their linkage to other streams of metabolism, and the cellular compartmentation of these processes. In addition to the principal lectures given at the Institute, many part1c1pants presented short reports for discussion and these are all included in this volume. The success of the Study Institute was due to the careful planning of the scientific programme to allow a smooth flow and integration of the topics included and this is reflected in the organisation of this book. The programme committee members were, R. Balazs (London), H. F. Bradford (London,Director), J. B. Clark (London), J. E. Cremer (MRC, Carshalton), J. S. Kelly (London), L. Lim (London), M. J. Neal (London) and P. J. Roberts (Southampton).

✦ Table of Contents

Front Matter....Pages i-xii
Nerve-Terminal Ultrastructure: A Role for Neurotubules?....Pages 1-13
Preparation of Synaptic Junctional Structures by Phase Partitioning in the Presence of n-Octyl-Glucoside....Pages 15-16
Molecular Composition of Synaptic Junctions and Post-Synaptic Densities: A Functional Perspective....Pages 17-38
Using Antibodies to Probe Brain Development....Pages 39-51
Glutamate Depolarization-Induced Release in the Cerebellum and its Regulation by GABA....Pages 53-77
Developmental Analysis of Neurotransmitter Systems in Rabbit Retina....Pages 79-97
Granular Vesicles of the Posterior Pituitary: A Model for Peptide Synthesis and Transport....Pages 99-100
Calmodulin Modulation of the Calcium Signal in Synaptic Transmission....Pages 101-120
The Study of Receptors and Ca Movements in Smooth Muscle as a Model for Presynaptic Events....Pages 121-137
Role for Contractile Proteins in Transmitter Release?....Pages 139-150
New Insights into Vesicle Recycling in a Model Cholinergic System....Pages 151-173
Pharmacology of the Acetylcholine Release evoked by One or a Few Nerve Impulses at the Nerve-Electroplaque Junction of Torpedo ....Pages 175-190
The Uptake and Metabolism of Choline Analogues by Cholinergic Nerve Terminals....Pages 191-209
Choline Uptake and Acetylcholine Release....Pages 211-217
In Vivo Regulation of Nigro-striatal and Mesocortico-prefrontal Dopaminergic Neurons....Pages 219-233
Acetylcholine-Dopamine Interactions in the Corpus Striatum and Nucleus Accumbens....Pages 235-252
Cholinergic Systems in the CNS....Pages 253-289
Distribution and Nature of Subpopulations of Muscarinic Receptors in the CNS as Judged by Receptor Binding....Pages 291-295
Regulation of Antagonist and Agonist Binding to the Muscarinic Acetylcholine Receptor by Protein Phosphorylation....Pages 297-298
GABA Enzymes and Pathways....Pages 299-327
GABA-Transaminase Inhibitors and Neuronal Function....Pages 329-344
GABA Synthesis: Its Dynamics in Relation to Glutamate and Glutamine Metabolism....Pages 345-357
Metabolic and Transmitter Compartments for Glutamate....Pages 359-378
Glutamate and Glutamine Transport in Cultured Neuronal and Glial Cells....Pages 379-382
Studies on Neuronal-Glial Metabolism of Glutamate in Cerebellar Slices....Pages 383-394
Amino Acid Compartments in Hippocampus: An Autoradiographic Approach....Pages 395-410
The Distribution and Regulation in Nerve Cells and Astrocytes of Certain Enzymes Associated with the Metabolic Compartmentation of Glutamate....Pages 411-429
Compartmentation of the Supply of the Acetyl Moiety for Acetylcholine Synthesis....Pages 431-460
Inter-Cell Regulation of Metabolism and Function....Pages 461-471
Macromolecular Interactions Between Neurons and Peripheral Glia in Cell Culture....Pages 473-496
Proliferation and Maturation of Neuronal Cells from the Central Nervous System in Culture....Pages 497-514
Certain Surface Properties of Isolated and Cultured Cerebellar Cells....Pages 515-534
Immunocytochemical Localization of Glutamic Acid Decarboxylase, Gamma-Aminobutyric Acid Transaminase in the Cerebellum....Pages 535-556
The Ultrastructural Localization of 5′-Nucleotidase in the Molecular Layer of the House Cerebellum....Pages 557-571
Monosodium Glutamate (M.S.G.) Effects on Arcuate Cells at Puberty....Pages 573-575
The Autoradiographic Localization of Baclofen-Sensitive GABA B Sites in Rat Cerebellum....Pages 577-583
Excitatory Amino Acids in the Cerebellum: Receptor Types and Receptive Cells....Pages 585-599
Physiological and Chemical Control of Hippocampal Neurones....Pages 601-616
The Postsynaptic Action of a Variety of Conventional and Non-Conventional Putative Neurotransmitters on Hippocampal Neurones....Pages 617-639
Synaptic Efficacy and Reliability in Perforant Pathway....Pages 641-649
Gonadal Steroid Action on Brain Sexual Differentiation and Sexual Behavior....Pages 651-663
Intracellular Compartmentation of the Oestrogen Receptor in the Female Rat Hypothalamus....Pages 665-674
Vasopressin and Oxytocin, Chemical Messengers in the Brain....Pages 675-685
A Procedure for the Characterisation of Identified Neuronal Pathways....Pages 687-689
Functional Morphology of Retinal Neurons with Monoamine or Amino Acid Neurotransmitters....Pages 691-718
Neuropeptides in the Vertebrate Retina....Pages 719-733
Excitatory, Inhibitory and Peptidergic Pathways in the Mudpuppy Retina....Pages 735-759
Transmitter Release from the Retina....Pages 761-785
Postnatal Development of a Mammalian Retina: Neurotransmitters as Physiological and Anatomical Probes....Pages 787-794
Cyclic Nucleotides in Retina....Pages 795-810
Neurotransmitter-Sensitive Adenylate Cyclase in the Teleost Retina....Pages 811-833
Back Matter....Pages 835-839

✦ Subjects

Neurosciences