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Neurotoxicity of contrast media for magnetic resonance imaging after generalized breakdown of the blood-brain barrier

โœ Scribed by Evill, Charles A.; Wilson, Alan J.; Fletcher, Margaret C.; Sage, Michael R.


Book ID
121984842
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
167 KB
Volume
3
Category
Article
ISSN
1076-6332

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The neurotoxicity of intravenously injected Gadolinium (Gd) complexes to rats with disrupted blood-brain barrier (BBB) was evaluated. After disruption of the BBB by infusion of mannitol solution, one of several contrast agents tested was injected intravenously at a dose of 1 or 3 mmol Gd/kg, and neu