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Neurotoxicant-induced animal models of Parkinson’s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration

✍ Scribed by Vladimir N. Uversky

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
434 KB
Volume
318
Category
Article
ISSN
0302-766X

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## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) inhibit the mitochondrial