𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The double-faced role of P2X7receptors in toxin-induced animal models of Parkinson’s disease

✍ Scribed by Beáta Sperlágh; Zsuzsanna Hracskó; Mária Baranyi; Cecília Csölle; Flóra Gölöncsér; Ágnes Kittel; Emilia Madarász

Publisher
BioMed Central
Year
2011
Tongue
English
Weight
67 KB
Volume
11
Category
Article
ISSN
1471-2210

No coin nor oath required. For personal study only.

✦ Synopsis

Sperlágh et al.: The double-faced role of P2X 7 receptors in toxin-induced animal models of Parkinson's disease. BMC Pharmacology 2011 11(Suppl 2):A56.

📜 SIMILAR VOLUMES

Effect of histamine H2 receptor antagoni
Effect of histamine H2 receptor antagonism on levodopa–induced dyskinesia in the MPTP-macaque model of Parkinson's disease
✍ Tom H. Johnston; Anne van der Meij; Jonathan M. Brotchie; Susan H. Fox 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

## Abstract Levodopa‐induced motor complications, including dyskinesia and wearing off, are troublesome side effects of treatment and impair quality of life in Parkinson's disease (PD) patients. The use of nondopaminergic agents as adjuncts to levodopa are potential options for managing these probl

Role of serotonin neurons in the inducti
Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease
✍ Manolo Carta; Thomas Carlsson; Ana Muñoz; Deniz Kirik; Anders Björklund 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB

## Abstract Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release d

Fipamezole (JP-1730) is a potent α2 adre
Fipamezole (JP-1730) is a potent α2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
✍ Juha-Matti Savola; Michael Hill; Mia Engstrom; Hannele Merivuori; Siegfried Wurs 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

Previous studies in the MPTP-lesioned primate model of Parkinson's disease have demonstrated that alpha(2) adrenergic receptor antagonists such as idazoxan, rauwolscine, and yohimbine can alleviate L-dopa-induced dyskinesia and, in the case of idazoxan, enhance the duration of anti-parkinsonian acti