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Neurotoxic action of lead: Effect on tetrahydrobiopterin metabolism in the rat

✍ Scribed by McIntosh, Morna J.; Meredith, Peter A.; Moore, Michael R.; Sir Abraham, Goldberg

Book ID: 123111089
Publisher: Elsevier Science
Year: 1985
Weight: 573 KB
Volume: 81
Category: Article
ISSN: 0306-4492
DOI: 10.1016/0742-8413(85)90120-3

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## Abstract Chronic (3 months) lead exposure increased the quinonoid dihydropteridine reductase activity and the tetrahydrobiopterin content but did not affect the GTP‐cyclohydrolase activity and the dihydrobiopterin content. These results suggest that lead intoxication may enhance dopamine metabol