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Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice

✍ Scribed by Claude Le Goascogne; Bernard Eychenne; Marie-Christine Tonon; François Lachapelle; Nicole Baumann; Paul Robel

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
601 KB
Volume
29
Category
Article
ISSN
0894-1491

No coin nor oath required. For personal study only.

✦ Synopsis

Concentrations of neurosteroids have been measured in the brains of postnatal myelin mutants jimpy (jp) and shiverer (shi) mice and of their normal controls. Progesterone (PROG) concentrations were increased more than threefold in the brains of mutant mice. Marked astroglial reaction occurs in the brains of jp mice and to a much smaller extent in shi ones. Whereas the mitochondrial benzodiazepine/diazepam binding inhibitor (DBI) receptor (MBR) was below the immunohistochemical detection limit in normal mice (except in the choroid plexus and ependyma cells), it was significantly expressed in many reactive astrocytes of jp and shi mice brains. DBI-like peptides, investigated either by immunohistochemistry or by radioimmunoassay, were expressed to similar extents in mutant and control mice. Reversed-phase HPLC indicated that DBI-like peptides were almost exclusively of the triakontatetraneuropeptide size. It was concluded that the increased expression of MBR (involved in the intramitochondrial delivery of cholesterol to P450scc) likely accounts for the large PROG content in mutant mice brain. The role of PROG in myelin repair is discussed.

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