𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Neuroscience and accelerator mass spectrometry

✍ Scribed by Magnus Palmblad; Bruce A. Buchholz; Darren J. Hillegonds; John S. Vogel

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
191 KB
Volume
40
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

Accelerator mass spectrometry (AMS) is a mass spectrometric method for quantifying rare isotopes. It has had a great impact in geochronology and archaeology and is now being applied in biomedicine. AMS measures radioisotopes such as ^3^H, ^14^C, ^26^Al, ^36^Cl and ^41^Ca, with zepto‐ or attomole sensitivity and high precision and throughput, allowing safe human pharmacokinetic studies involving microgram doses, agents having low bioavailability or toxicology studies where administered doses must be kept low (<1 Β΅g kg^βˆ’1^). It is used to study long‐term pharmacokinetics, to identify biomolecular interactions, to determine chronic and low‐dose effects or molecular targets of neurotoxic substances, to quantify transport across the blood–brain barrier and to resolve molecular turnover rates in the human brain on the time‐scale of decades. We review here how AMS is applied in neurotoxicology and neuroscience. Copyright Β© 2005 John Wiley & Sons, Ltd.

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