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Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease

✍ Scribed by Lee, Kang-Woo; Im, Joo-Young; Woo, Jong-Min; Grosso, Hilary; Kim, Yoon-Seong; Cristovao, Ana Clara; Sonsalla, Patricia K.; Schuster, David S.; Jalbut, Marla M.; Fernandez, Jose R.; Voronkov, Michael; Junn, Eunsung; Braithwaite, Steven P.; Stock, Jeffry B.; Mouradian, M. Maral

Book ID
118303078
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
575 KB
Volume
10
Category
Article
ISSN
1933-7213

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o