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Neuroprotective action of donepezil mediated by neuronal nicotinic receptors

✍ Scribed by Akinori AKAIKE; Hiroshi KATSUKI; Toshiaki KUME; Yuki TAKADA-TAKATORI


Book ID
115302215
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
504 KB
Volume
6
Category
Article
ISSN
1346-3500

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Mechanism of neuroprotection by donepezi
✍ Yuki Takada-Takatori; Toshiaki Kume; Yuta Ohgi; Yasuhiko Izumi; Tetsuhiro Niidom πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 218 KB

## Abstract Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 ΞΌM, 4 days) up‐regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil‐induced neuroprotection in ne