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Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease

✍ Scribed by K. Xu; Y.-H. Xu; J.-F. Chen; M.A. Schwarzschild

Book ID
116789171
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
496 KB
Volume
167
Category
Article
ISSN
0306-4522

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o