✦ LIBER ✦

Neurophysiological assessment in the diagnosis of botulism: Usefulness of single-fiber EMG

✍ Scribed by Luca Padua; Irene Aprile; Mauro Lo Monaco; Lucia Fenicia; Fabrizio Anniballi; Flavia Pauri; Pietro Tonali

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 96 KB
Volume: 22
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199910)22:10<1388::aid-mus8>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

We report the clinical, serological, and neurophysiological findings in seven patients with foodborne botulism caused by ingestion of black olives in water. The clinical picture was characterized by mild symptoms with a long latency of onset and by involvement of cranial and upper limb muscles; only one patient, a child, developed respiratory failure. Spores of Clostridium botulinum were found in stools in some but not all cases. Conventional neurophysiological tests had low sensitivity; abnormal findings were present only in the patient with severe clinical involvement, in whom compound muscle action potentials (CMAPs) appeared reduced. Repetitive nerve stimulation at a high rate showed pseudofacilitation and not true posttetanic facilitation, but single-fiber electromyography (SFEMG) showed abnormalities of neuromuscular transmission in every case. Neurophysiological evaluation, particularly SFEMG, is important because it allows rapid identification of abnormal neuromuscular transmission while bioassay studies are in progress.

📜 SIMILAR VOLUMES

Stimulated single fiber EMG of the front

Stimulated single fiber EMG of the frontalis muscle in the diagnosis of ocular myasthenia

✍ J. Valls-Canals; J. Montero; J. Pradas 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 2 views

We performed single fiber electromyography by axonal stimulation (SFEMG-AS) of the frontalis muscle of 16 patients with ocular myasthenia gravis (OM) and 33 controls. In the controls, values of mean consecutive differences (MCD) ranged from 5 to 55 micros (average, 14.7 +/- 2.8 micros) and mean MCD

AAEM practice topics: Technology assessm

AAEM practice topics: Technology assessment: The use of surface EMG in the diagnosis and treatment of nerve and muscle disorders

✍ Andrew J. Haig; Jeffrey B. Gelblum; James J. Rechtien; Andrew J. Gitter 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB 👁 2 views

Assessment of the reliability of single

Assessment of the reliability of single blastomere analysis for preimplantation diagnosis of the ΔF508 deletion causing cystic fibrosis in clinical practice

✍ Pierre F. Ray; Asangla Ao; Deborah M. Taylor; Robert M. L. Winston; Alan H. Hand 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

Following the birth of a baby girl confirmed to be homozygous normal for the delta F508 deletion causing cystic fibrosis (CF), many single-gene defects have been diagnosed by polymerase chain reaction (PCR) for preimplantation genetic diagnosis (PGD). A few misdiagnoses have been reported but no lar

An assessment of the use of interphase F

An assessment of the use of interphase FISH with chromosome specific probes as an alternative to cytogenetics in prenatal diagnosis

✍ Angela T. A. Thein; Sherif A. Abdel-Fattah; Phillipa M. Kyle; Peter W. Soothill 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 1 views

We have assessed the effects that would have been observed if we had changed from standard prenatal diagnosis to interphase ¯uorescence in situ hybridization (FISH) on our amniocentesis samples. We aimed to estimate the number of cases with aberrations other than chromosomes 13, 18, 21, X and Y, whi

Diagnosis of bladder cancer by analysis

Diagnosis of bladder cancer by analysis of the allelic loss of the p53 gene in urine samples using blunt-end single-strand conformation polymorphism

✍ Kokichi Sugano; Masakazu Tsutsumi; Yuki Nakashima; Kensei Yamaguchi; Hisanao Ohk 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 64 KB 👁 1 views

The novel approach of blunt-end single-strand conformation polymorphism (SSCP) has been applied in the analysis of urine samples from bladder-cancer patients for detecting loss of heterozygosity (LOH) of 3 polymorphic markers in the p53 gene. Of the 28 urine samples examined by SSCP analysis of blun

Assessment of aniline derivatives-induce

Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis (“comet”) assay

✍ Barbara Przybojewska 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 28 KB 👁 1 views

The alkaline single cell gel electrophoresis (SCGE) or "comet" assay under alkaline conditions was used to measure DNA damage in the liver cells of B6C3F1 male mice exposed to 2,4-dimethylaniline and 2,4,6-trimethylaniline. Cells embedded in agarose were lysed, subjected briefly to an electric field