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Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory

✍ Scribed by Toshio Kawamata; Ichiro Akiguchi; Hideo Yagi; Mika Irino; Hiroshi Sugiyama; Haruhiko Akiyama; Atsushi Shimada; Manabu Takemura; Masaki Ueno; Takamichi Kitabayashi; Katsunori Ohnishi; Naoyuki Seriu; Keiichi Higuchi; Masanori Hosokawa; Toshio Takeda


Book ID
114254110
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
662 KB
Volume
32
Category
Article
ISSN
0531-5565

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Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of system

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Memory, learning and behavior of senescence accelerated mouse (SAM-P/8) were investigated by using passive avoidance response, T-maze and open field and the findings were compared with those from senescence resistant mouse (SAM-R/1 control). SAM-P/8 mice showed a remarkable age-related deterioration