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Neurons express proteins of the classical complement pathway in Alzheimer disease

✍ Scribed by K Terai; D.G Walker; E.G McGeer; P.L McGeer

Book ID
114003118
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
842 KB
Volume
769
Category
Article
ISSN
0006-8993

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In both trisomy 21 and rare cases of triplication of amyloid precursor protein (APP) Alzheimer's disease (AD) pathological changes are believed to be secondary to increased expression of APP. We hypothesized that sporadic AD may also be associated with changes in transcription of APP or its metabol