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Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport

✍ Scribed by Laura Torroja; Hsin Chu; Irina Kotovsky; Kalpana White


Book ID
114321563
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
101 KB
Volume
9
Category
Article
ISSN
0960-9822

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A characteristic neuropathological feature of Alzheimer's disease is the cerebral deposition of amyloid plaques. These deposits contain PA4 amyloid peptide, a cleavage product of the transmembrane protein amyloid protein precursor (APP). Despite numerous studies on the processing of the different AP